Grady Health System has received $30 million from the Marcus Foundation to help expand its hospital’s emergency department and its stroke and neuroscience center.

It’s the second huge gift to Grady from the foundation, created by Home Depot co-founder Bernie Marcus.

Grady said Monday that $20 million of the donation would go toward building its new emergency center, while the remainder would help expand the stroke center.

“This incredibly generous gift brings the Marcus Foundation’s total investment in Grady to $50 million since 2009,” said Grady President and CEO John Haupert in a statement.

Atlanta’s largest safety-net hospital has reached more solid financial footing under new leadership, after enduring years of big deficits.

Since Grady’s 2008 restructuring, philanthropic donations have helped transform the hospital.

The Woodruff Foundation, for instance, committed $200 million over four years for medical equipment.

A Marcus Foundation gift of $20 million in 2009 paved the way for the opening of the Marcus Stroke and Neuroscience Center the following year.

“The state-of-the-art Marcus Stroke and Neuroscience Center and the Marcus Trauma Center have saved thousands of lives,’’ Haupert said. “This new funding will allow Grady to enhance its role as the state’s leading provider of emergency care and make our outpatient neurology services among the best in the nation.”

Marcus said in a statement that the foundation’s support “is a testament to our firm belief that Grady is essential to the health and well-being of not just Atlanta and the metro area, but the entire state of Georgia.”

“By helping to create and expand its nationally and internationally renowned emergency and stroke services, the Marcus Foundation is making an investment that we believe will make Grady the national standard of emergency care,” Marcus said.

Work on the emergency department expansion and redesign began earlier this year and is expected to be completed in 2016. The Marcus gift will be combined with $50 million in other philanthropic donations to fund the project.

“We are extremely grateful to the Marcus Foundation for their generosity and their confidence in Grady’s future,” A.D. “Pete” Correll, chairman of the Grady Memorial Hospital Corporation Board of Directors, said in a statement. “Their investments in Grady have been instrumental to our transformation and serves as an endorsement of Grady’s enormous and unique value to our community.”