With more than 200,000 lives lost to COVID-19, the U.S. is facing a reckoning on science and politics. Even basic scientific research, like whether to wear a mask in a pandemic, is now being seen through the lens of the 2020 election and Trump politics. That’s a big problem, health officials say, because to overcome the pandemic, most Americans will have to agree on basic steps to stop the spread of the virus, whether it’s wearing a mask or accepting a vaccine.

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